Platelet-Derived Growth Factor Receptors

Specific receptors on cell membranes that react with PLATELET-DERIVED GROWTH FACTOR, its analogs, or antagonists. The alpha PDGF receptor (RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA) and the beta PDGF receptor (RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA) are the two principle types of PDGF receptors. Activation of the protein-tyrosine kinase activity of the receptors occurs by ligand-induced dimerization or heterodimerization of PDGF receptor types.

Also Known As:

Platelet-Derived Growth Factor Receptor; Receptors, Platelet Derived Growth Factor; Receptors, Platelet-Derived Growth Factor; PDGF Receptor; Platelet Derived Growth Factor Receptor; Platelet Derived Growth Factor Receptors; Receptor, PDGF; PDGF Receptors; Receptors, PDGF

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Transferases: 6719
    - Phosphotransferases: 43773
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9899
        Protein-Tyrosine Kinases: 7827
        Receptor Protein-Tyrosine Kinases: 6127
        Platelet-Derived Growth Factor Receptors: 2208
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Membrane Proteins: 10262
    - Cell Surface Receptors: 2156
      - Receptor Protein-Tyrosine Kinases: 6127
        Platelet-Derived Growth Factor Receptors: 2208
      - Peptide Receptors: 1208
        Growth Factor Receptors: 2687
        Platelet-Derived Growth Factor Receptors: 2208
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein-Tyrosine Kinases: 7827
      - Receptor Protein-Tyrosine Kinases: 6127
        Platelet-Derived Growth Factor Receptors: 2208

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Disease

Drug/Important Bio-Agent (IBA)